Situated on opposite sides of the Pacific Ocean, the US Pacific Northwest Region and Japan face significant earthquake risks from similar geophysical conditions. The Pacific Northwest is considered overdue for a Cascadia Subduction Zone 8.0–9.2 magnitude megaquake. When it happens, the estimated direct fatalities for Oregon and Washington states are up to 10,000, with economic losses of more than $80 billion. For the comparably sized region of Japan facing a Nankai megathrust earthquake, estimated fatalities are 80,000–323,000 lives and about $900 billion in economic loss.